Serum leptin and ghrelin in chronic hepatitis C patients with steatosis

Table 4 Leptin and ghrelin concentrations at baseline and at end of follow-up by response to treatment in patients with hepatitis C virus genotypes-1 and -3, as well as mixed effect model derived estimates of the differences in mean scores (mean ± SD)

Variable	Baseline	End of follow-up	P-value for the adjusted difference1
Genotype 1 SVRs
Leptin (ng/mL)	37.66 (10.39)	26.69 (11.77)	0.001
Ghrelin (ng/mL)	0.286 (0.167)	0.456 (0.254)	0.001
Genotype 1 non-SVRs
Leptin (ng/mL)	49.67 (13.44)	43.58 (16.17)	0.060
Ghrelin (ng/mL)	0.190 (0.119)	0.239 (0.213)	0.320
Genotype 3 SVRs
Leptin (ng/mL)	24.33 (7.98)	23.27 (9.54)	0.510
Ghrelin (ng/mL)	0.778 (0.654)	0.420 (0.321)	0.001
Genotype 3 non-SVRs
Leptin (ng/mL)	28.20 (9.72)	26.70 (6.82)	0.610
Ghrelin (ng/mL)	0.564 (0.324)	0.450 (0.261)	0.470

¹Adjusted for both leptin and ghrelin concentrations.