CpG island methylator phenotype in plasma is associated with hepatocellular carcinoma prognosis

Table 2 Frequencies of gene methylation in hepatocellular carcinomas, corresponding non-neoplastic liver tissues and normal liver tissues

Genes	No. of methylated samples
	Tumor (n = 108)	Plasma (n = 108)	Non-neoplastic tissues (n = 102)	NormalTissues (n = 15)	Healthy plasma (n = 60)	χ2
APC	481	26	5	0	0	43.47
WIF- 1	531	35	6	0	0	48.44
DLC-1	381	23	4	0	0	32.05
DKK	391	25	5	0	0	30.85
SFRP-1	481	26	5	0	0	43.47
E-cad-1	371	18	3	0	0	33.37
RUNX3	521	42	4	0	0	52.47

¹χ² test comparing the frequencies of gene methylation between tumor and non-neoplastic samples, P < 0.05.