Down-regulation of STAT3 expression by vector-based small interfering RNA inhibits pancreatic cancer growth

Figure 1 Signal transduction and activation of transcription 3 expression in human pancreatic cancer cells. A: Western blotting analysis of STAT3 and p-STAT3 expression in PANC-1, SW1990, pancreatic cancer, and normal pancreatic tissue with 100 μg total protein for each sample; B: Immunohistochemical analysis of STAT3 expression: pancreatic cancer tissue shows a high-density staining for STAT3 while normal pancreatic tissues show a low-density staining; C: Immunohistochemical analysis of p-STAT3 expression: pancreatic cancer tissue shows a high-density staining for p-STAT3 while normal pancreatic tissues does not show any staining. STAT3: Signal transduction and activation of transcription 3.