Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease

Table 4 Odds ratio for the gene polymorphisms among Crohn’s disease and ulcerative colitis never smokers

	NS-CD	NS-UC	NS-control	ORNS-CD	95% CI1	P value	ORNS-UC	95% CI1	P value	ORNS-IBD	95% CI1	P value
NF-κB -94ins/del
II	40	79	136	1.00	-		1.00	-		1.00	-
ID	56	109	194	0.99	0.62-1.57	0.97	0.98	0.68-1.42	0.93	0.98	0.71-1.36	0.92
DD	19	38	61	1.07	0.57-2.00	0.83	1.09	0.67-1.79	0.72	1.09	0.70-1.68	0.71
ID and DD	75	147	255	1.01	0.65-1.56	0.97	1.01	0.72-1.43	0.95	1.01	0.74-1.37	0.96
PPARγ Pro12Ala
CC	83	167	270	1.00	-		1.00	-		1.00	-
CG	31	50	117	0.86	0.54-1.38	0.54	0.71	0.48-1.04	0.08	0.75	0.54-1.05	0.09
GG	1	9	4	0.80	0.09-7.29	0.84	3.99	1.20-13.32	0.02	2.77	0.85-9.00	0.09
CG and GG	32	59	121	0.86	0.54-1.37	0.53	0.81	0.56-1.17	0.26	0.82	0.59-1.13	0.21
PPARγ C1431T
CC	85	163	285	1.00	-		1.00	-		1.00	-
CT	26	56	100	0.88	0.53-1.44	0.60	0.98	0.67-1.44	0.93	0.93	0.67-1.31	0.70
TT	4	7	6	2.16	0.59-7.90	0.24	2.05	0.67-6.26	0.21	2.06	0.75-5.67	0.16
CT and TT	30	63	106	0.95	0.59-1.53	0.83	1.04	0.72-1.51	0.82	1.00	0.72-1.39	0.99
PXR rs1523127
AA	43	74	149	1.00	-		1.00	-		1.00	-
AC	51	103	176	1.01	0.64-1.60	0.97	1.15	0.79-1.67	0.46	1.11	0.80-1.53	0.54
CC	21	49	66	1.10	0.60-1.99	0.77	1.52	0.95-2.41	0.08	1.36	0.90-2.05	0.15
AC and CC	72	152	242	1.03	0.67-1.59	0.89	1.25	0.88-1.77	0.21	1.17	0.87-1.59	0.30
PXR rs2276707
CC	73	150	260	1.00	-		1.00	-		1.00	-
CT	36	70	119	1.08	0.69-1.70	0.74	1.03	0.72-1.47	0.89	1.04	0.76-1.43	0.81
TT	6	6	12	1.76	0.64-4.86	0.27	0.86	0.31-2.34	0.76	1.16	0.51-2.63	0.73
CT and TT	42	76	131	1.14	0.74-1.76	0.55	1.01	0.71-1.43	0.96	1.05	0.77-1.43	0.75
PXR rs6785049
AA	42	77	168	1.00	-		1.00	-		1.00	-
AG	52	119	176	1.19	0.75-1.88	0.47	1.49	1.04-2.13	0.03	1.38	1.01-1.89	0.05
GG	21	30	47	1.79	0.97-3.31	0.06	1.40	0.82-2.39	0.22	1.53	0.97-2.43	0.07
AG and GG	73	149	223	1.31	0.85-2.02	0.21	1.47	1.04-2.07	0.03	1.41	1.05-1.91	0.02
LXR rs1405655
TT	43	95	203	1.00	-		1.00	-		1.00	-
CT	55	106	154	1.69	1.07-2.65	0.02	1.54	1.08-2.18	0.02	1.58	1.16-2.16	0.004
CC	17	25	34	2.32	1.19-4.55	0.01	1.66	0.93-2.95	0.09	1.85	1.12-3.07	0.02
CT and CC	72	131	188	1.80	1.18-2.77	0.01	1.56	1.11-2.17	0.01	1.63	1.21-2.20	0.001
LXR rs2695121
TT	15	30	90	1.00	-		1.00	-		1.00	-
CT	59	126	197	1.82	0.98-3.39	0.06	1.98	1.23-3.17	0.005	1.93	1.28-2.92	0.002
CC	41	70	104	2.37	1.23-4.57	0.01	2.09	1.25-3.49	0.005	2.18	1.39-3.41	0.0007
CT and CC	100	196	301	2.01	1.11-3.64	0.02	2.01	1.28-3.17	0.002	2.02	1.36-2.99	0.0005

Statistical analyses included subjects for whom all information was available.

¹Adjusted for age and sex. NS: Never smoker; NF-κB: Nuclear factor κB; PPARγ: Peroxisome proliferator-activated receptor γ; CD: Crohn’s disease; UC: Ulcerative colitis; OR: Odds ratio; PXR: Pregnane X receptor; LXR: Liver X receptor.