Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease

Table 3 Odds ratio for the studied gene polymorphisms in Crohn’s disease and ulcerative colitis patients

	CD	UC	Control	ORCD	95% CI1	P value	ORUC	95% CI1	P value
NF-κB -94ins/del
II	107	175	267	1.00	-		1.00	-
ID	165	233	385	1.08	0.80-1.46	0.62	0.94	0.72-1.21	0.62
DD	55	87	127	1.21	0.81-1.81	0.36	1.04	0.73-1.47	0.83
ID and DD	220	320	512	1.11	0.83-1.48	0.48	0.96	0.75-1.23	0.76
PPARγ Pro12Ala
CC	240	364	549	1.00	-		1.00	-
CG	84	116	217	0.88	0.65-1.20	0.43	0.83	0.63-1.09	0.17
GG	3	15	13	0.48	0.13-1.77	0.27	2.30	1.04-5.08	0.04
CG and GG	87	131	230	0.86	0.64-1.16	0.33	0.90	0.69-1.17	0.42
PPARγ C1431T
CC	241	352	561	1.00	-		1.00	-
CT	78	128	205	0.81	0.59-1.12	0.20	1.00	0.76-1.31	0.99
TT	8	15	13	1.36	0.54-3.42	0.52	1.95	0.90-4.27	0.09
CT and TT	86	143	218	0.85	0.62-1.15	0.29	1.05	0.81-1.37	0.69
PXR rs1523127
AA	114	160	280	1.00	-		1.00	-
AC	167	250	366	1.06	0.79-1.43	0.71	1.15	0.89-1.50	0.29
CC	46	85	133	0.89	0.59-1.35	0.59	1.11	0.78-1.56	0.57
AC and CC	213	335	499	1.02	0.77-1.35	0.91	1.14	0.89-1.46	0.30
PXR rs2276707
CC	223	339	517	1.00	-		1.00	-
CT	94	147	241	0.92	0.68-1.24	0.57	0.97	0.75-1.26	0.84
TT	10	9	21	1.25	0.56-2.76	0.58	0.67	0.30-1.51	0.33
CT and TT	104	156	262	0.94	0.71-1.26	0.69	0.95	0.74-1.22	0.68
PXR rs6785049
AA	137	184	334	1.00	-		1.00	-
AG	152	247	343	1.12	0.84-1.49	0.46	1.35	1.05-1.74	0.02
GG	38	64	102	0.91	0.58-1.40	0.66	1.18	0.81-1.71	0.39
AG and GG	190	311	445	1.07	0.81-1.40	0.65	1.31	1.03-1.66	0.03
LXR rs1405655
TT	143	229	383	1.00	-		1.00	-
CT	149	217	313	1.26	0.95-1.68	0.11	1.22	0.95-1.57	0.11
CC	35	49	83	1.12	0.71-1.78	0.62	1.01	0.67-1.51	0.97
CT and CC	184	266	396	1.23	0.94-1.62	0.13	1.18	0.93-1.49	0.17
LXR rs2695121
TT	62	88	170	1.00	-		1.00	-
CT	168	254	387	1.28	0.90-1.83	0.17	1.30	0.95-1.77	0.10
CC	97	153	222	1.21	0.82-1.79	0.34	1.41	1.00-1.98	0.05
CT and CC	265	407	609	1.26	0.89-1.76	0.19	1.34	0.99-1.79	0.06

Statistical analyses included subjects for whom all information was available.

¹Adjusted for age, sex and smoking status. NF-κB: Nuclear factor κB; PPARγ: Peroxisome proliferator-activated receptor γ; CD: Crohn’s disease; UC: Ulcerative colitis; OR: Odds ratio; PXR: Pregnane X receptor; LXR: Liver X receptor.