Polymorphisms in NF-&kappa;B, PXR, LXR, PPAR&gamma; and risk of inflammatory bowel disease

doi:10.3748/wjg.v17.i2.197

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2011; 17(2): 197-206
Published online Jan 14, 2011. doi: 10.3748/wjg.v17.i2.197

Table 1 Description of study participants n (%)

	CD (n = 327)	UC (n = 495)	Controls (n = 779)
Sex
Male	129 (39)	239 (48)	400 (51)
Female	198 (61)	256 (51)	379 (49)
Age (yr)
Median (5%-95%)	43 (23-76)	49 (24-76)	43 (23-60)
Age at diagnosis (yr)
Median (5%-95%)	30 (15-64)	35 (17-68)
Smoking habits
Smokers	167 (51)	86 (17)	205 (26)
Never smokers	115 (35)	226 (46)	391 (50)
Former smokers	45 (14)	183 (37)	183 (23)
Location of UC
Proctitis (E1)		207 (42)
Left side (E2)		183 (37)
Extensive (E3)		93 (19)
Data not available		12 (2)
Location of CD
Colonic (L2)	151 (46)
Ileal (L1)	74 (23)
Ileocolonic (L3)	89 (27)
Data not available	13 (4)
Medication
Advanced¹	140 (43)	103 (21)
No advanced medication²	182 (56)	389 (79)
Data not available	5 (2)	3 (1)
Operation
Yes	149 (46)	14 (3)
No	171 (52)	472 (95)
Data not available	7 (2)	9 (2)

Disease location was classified according to the WGO Montreal classification. Statistical analyses included subjects for whom all information was available.

¹Azathioprine, 6-mercaptopurine, tumor necrosis factor inhibitors, or methrotrexate;

²5-aminosalicylic acid, prednisolone. CD: Crohn’s disease; UC: Ulcerative colitis.

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Citation: Andersen V, Christensen J, Ernst A, Jacobsen BA, Tjønneland A, Krarup HB, Vogel U. Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease. World J Gastroenterol 2011; 17(2): 197-206
URL: https://www.wjgnet.com/1007-9327/full/v17/i2/197.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i2.197

Andersen V, Christensen J, Ernst A, Jacobsen BA, Tjønneland A, Krarup HB, Vogel U. Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease. World J Gastroenterol 2011; 17(2): 197-206 [PMID: 21245992 DOI: 10.3748/wjg.v17.i2.197]

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