SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are prognosis-related in colorectal cancer

Table 2 Expression of candidate markers in 156 colorectal cancer patients

Markers	Numbers of patients with different expression1
	Negative	Low	Medium	High
P53	42	36	32	40
APC	80	37	21	10
MAPK	114	27	8	0
E-cadherin	44	47	36	22
Mmp9	109	40	6	1
Hsp27	96	33	18	6
MSH2	17	52	47	39
P21ras	102	43	8	2
ADCY-2	45	67	36	3
Shp2	108	34	13	0
ETB	59	60	30	5
Neuroligin	53	52	43	4
Rho	28	68	45	9
SPARCL1	23	52	61	20

The immunohistochemical (IHC) results were assessed using a semi-quantitative system, as previously described[8]. According to the percentages of positive cells and staining intensity, the expression levels of the proteins were divided into four groups as negative, low, medium and high expression.

¹Data were missing because some specimens were lost during sectioning and staining of tissue arrays.