Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis

doi:10.3748/wjg.v16.i8.973

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 8

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (4628)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-3) series, Tables (1-4) series.

Item

Count

PDF

345

HTML

3951

Figures (1-3)

181

Tables (1-4)

151

Sum=4628

Feb 28, 2010 (publication date) through Apr 23, 2024

Times Cited of This Article

Times Cited (14)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Brief Article

World J Gastroenterol. Feb 28, 2010; 16(8): 973-981
Published online Feb 28, 2010. doi: 10.3748/wjg.v16.i8.973

Table 4 Reactivity of sera from 95 anti-M2 positive PBC patients with different peptide conjugates containing the reported immunodominant epitope of PDC-E2[6,12]

Peptides of the inner lipoyl domain	IgG-antibodies			IgM-antibodies
Peptides of the inner lipoyl domain	Positive n (%)	mean absorbance × 1000 ± SD (median)	Cut off value	Positive n (%)	mean absorbance × 1000 ± SD (median)	Cut off value
152-176 (present study peptide 10)	28 (29)	153 ± 243 (87)	150	35 (37)	95 ± 77 (73)	80
169-193 (present study peptide 11)	11 (12)	210 ± 219 (157)	300	37 (39)	143 ± 120 (101)	120
167-184	0	113 ± 63 (93)	100	5 (5)	53 ± 79 (20)	100
167-184-LA	3 (3)	135 ± 71 (111)	100	10 (11)	78 ± 107 (40)	100
OVA-167-184¹	42 (44)	316 ± 260 (271)	100	54 (57)	254 ± 318 (117)	100
OVA-167-184-LA¹	21 (22)	175 ± 280 (148)	100	29 (31)	113 ± 217 (52)	100

¹After subtraction of reactivity to OVA alone.

Citation: Braun S, Berg C, Buck S, Gregor M, Klein R. Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis. World J Gastroenterol 2010; 16(8): 973-981
URL: https://www.wjgnet.com/1007-9327/full/v16/i8/973.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i8.973