Redefining the properties of an osmotic agent in an intestinal-specific preservation solution

doi:10.3748/wjg.v16.i45.5701

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Dec 7, 2010 (publication date) through May 1, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2010; 16(45): 5701-5709
Published online Dec 7, 2010. doi: 10.3748/wjg.v16.i45.5701

Table 2 Intestinal morphology following cold ischemic storage

Time (h)	Group	Grade	Median	Significance	Event
2	D1	0, 2, 6, 7	4		Denuded villi
	D2	3, 4, 6, 6	5		Loss of villi
	D3	1, 2, 2, 3	2	D3, D4, D5 vs D1, D2, P = 0.06	Moderate clefting
	D4	1, 2, 3, 5	2.5		Moderate-extensive clefting
	D5	1, 2, 3, 4	2.5		Moderate-extensive clefting
12	D1	0, 6, 7, 8	6.5		Injury to crypts and submucosa
	D2	2, 6, 7, 7	6.5		Injury to crypts and submucosa
	D3	3, 7, 8, 8	7.5		Injury to crypts, submucosa and muscularis
	D4	3, 6, 8, 8	7		Injury to crypts and submucosa
	D5	0, 4, 4, 5	4	D5 vs D1-D4, P < 0.05	Clefting and denuded villi

A modified Park’s classification for intestinal injury was used to assess mucosal morphology as follows: Grade 0: Normal mucosa; Grade 1: Subepithelial space at villus tip; Grade 2: Moderate subepithelial space; Grade 3: Epithelial lifting along villus sides; Grade 4: Denuded villi; Grade 5: Loss of villus tissue; Grade 6: Crypt layer injury; Grade 7: Transmucosal injury; Grade 8: Transmural injury.

Citation: Schlachter K, Kokotilo MS, Carter J, Thiesen A, Ochs A, Khadaroo RG, Churchill TA. Redefining the properties of an osmotic agent in an intestinal-specific preservation solution. World J Gastroenterol 2010; 16(45): 5701-5709
URL: https://www.wjgnet.com/1007-9327/full/v16/i45/5701.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i45.5701