Consequences of Helicobacter pylori infection in children

Table 2 Randomized trials of Helicobacter pylori eradication for iron deficiency anemia and iron deficiency in children

Author (yr)/country	No. of children with IDA/H. pylori	Follow-up (No. of children)	Outcome
			IDA	ID
Choe et al[89] (1999)/Korea	43/25	8 wk (18)	Hb increased with: eradication + iron, eradication + placebo vs iron + placebo (P = 0.0086)	No significant differences in serum iron or ferritin
Sarker et al[106] (2008)/Bangladesh	260/200	3 mo (260)	IDA persisted with: eradication + iron, 11%; eradication alone, 33%; iron alone, 0%; placebo, 45%	ID persisted with: eradication + iron, 19%; eradication alone, 65%; iron alone, 7%; placebo, 78%
Gessner et al[105] (2006)/Alaska	219/219	14 mo (201)	IDA persisted with: eradication + iron, 22%; iron alone, 14%	ID persisted with: eradication + iron, 65%; iron alone, 72%
Fagan et al[104] (2009)/Alaska	219/219	40 mo (176)	IDA persisted with: eradication + iron, 5%; iron alone, 19%	ID persisted with: eradication + iron, 52%; iron alone, 58%

Hb: Hemoglobin; ID: Iron deficiency; IDA: Iron deficiency anemia; H. pylori: Helicobacter pylori.