Diagnosis and management of angioedema with abdominal involvement: A gastroenterology perspective

Table 2 Distinguishing features of angioedemas[8,27,28,33]

	HAE	Inherited	AA	Idiopathic	ACE-I	NSAID	Allergic
Location	Anywhere	Anywhere	Anywhere	Especially lips and face	Especially lips, tongue, intestines	Especially face	Anywhere
Urticaria	No	No	No	Usually	Rare	Usually	Usually
Family history	Yes	Yes	No	No	No	No	No
Age of onset	6-20 yr	6-20 yr	> 40 yr	Any age	Any age	Any age	Any age
Trauma as trigger	Yes	Yes	Yes	No	No	No	No
C1q	Normal	Normal	Low (type 1)	Normal	Normal	Normal	Normal
			Low/normal (type 2)
C1 INH levels	Low (type 1)	Normal	Low (type 1)	Normal	Normal	Normal	Normal
	Normal (type 2)		Low/normal (type 2)
C1 INH function	Low (type 1)	Normal	Low	Normal	Normal	Normal	Normal
	Low (type 2)
C4	Low	Normal	Low	Normal	Normal	Normal	Normal
C3	Normal	Normal	Low/normal	Normal	Normal	Normal	Normal

HAE: Hereditary angioedema; AA: acquired angioedema; ACE-I: Angiotensin converting enzyme inhibitor; NSAID: Non-steroidal anti-inflammatory drug; C1 INH: C1 esterase inhibitor.