mPGES-1 expression in non-cancerous liver tissue impacts on postoperative recurrence of HCC

Table 2 Univariate analysis of clinicopathological features related to postoperative recurrence

	No. of patients	Postoperative recurrence		P
		Yes	No
Age (yr)
≥ 60	45	23	22	0.733
< 60	19	9	10
Gender
Male	43	20	23	0.481
Female	21	12	9
Hepatitis B surface antigen
Positive	21	13	8	0.147
Negative	43	19	24
Hepatitis C virus antibody
Positive	32	12	20	0.151
Negative	32	20	12
Total bilirubin (mg/dL)
≥ 1.0	29	7	22	0.987
< 1.0	35	13	22
Alanine aminotransferase (IU/L)
≥ 50	26	11	15	0.635
< 50	38	21	17
Albumin (g/dL)
≥ 3.7	49	24	25	0.022
< 3.7	15	13	2
Platelets (104/μL)
≥ 10	46	21	25	0.465
< 10	18	11	7
Liver cirrhosis
Present	31	16	15	0.772
Absent	33	16	17
T mPGES-1
High	21	12	9	0.925
Low	43	25	18
NC mPGES-1
High	35	23	11	0.006
Low	29	9	21
Hepatectomy
Anatomic	31	21	10	0.149
Non-anatomic	33	16	17
Operative blood loss (mL)
≥ 500	15	12	3	0.091
< 500	49	25	24
α-fetoprotein (ng/mL)
≥ 100	15	10	5	0.347
< 100	49	27	22
DCP (mAU/mL)
≥ 400	22	15	7	0.081
< 400	42	19	23
Tumor diameter (cm)
≥ 5	16	12	3	0.018
< 5	48	20	29
Tumor number
Multiple	7	3	4	0.789
Solitary	57	29	28
Histological grade
Well	18	8	10	0.495
Moderate	40	21	19
Poor	6	3	3
Capsular formation
Present	49	25	24	0.320
Absent	5	7	8
Vascular invasion
Present	16	11	5	< 0.001
Absent	48	9	39

DCP: Des-γ-carboxy prothrombin; mPGES-1: Microsomal prostaglandin E synthase-1; T mPGES-1: mPGES-1 expression in hepatocellular carcinoma tumor tissue; NC mPGES-1: mPGES-1 expression in non-cancerous liver tissue.