Mn-SOD and CuZn-SOD polymorphisms and interactions with risk factors in gastric cancer

Table 5 Interaction of SOD1 G7958A and environmental factors for gastric cancer development

Factors	SOD1	HC (%)	GC (%)	1OR (95% CI)	β	γ = βeg/βe
		n = 147	n = 140
Alcohol
No	GG	58 (39.5)	10 (7.1)	1.00
No	A/-	42 (28.6)	45 (32.1)	6.00 (2.70-13.33)	1.79
Yes	GG	21 (14.3)	29 (20.7)	10.30 (3.94-26.91)	2.33
Yes	A/-	26 (17.7)	56 (40.0)	16.50 (6.67-40.86)	2.80	1.20
Family history
Negative	GG	73 (49.7)	25 (17.9)	1.00
Negative	A/-	62 (42.2)	74 (52.9)	3.58 (2.02-6.37)	1.28
Positive	GG	6 (4.1)	14 (10.0)	7.70 (2.63-22.51)	2.04
Positive	A/-	6 (4.1)	27 (19.3)	15.56 (5.57-43.50)	2.75	1.35
Type I H. pylori
Negative	GG	55 (37.4)	10 (7.1)	1.00
Negative	A/-	27 (18.4)	22 (15.7)	4.48 (1.84-10.91)	1.50
Positive	GG	24 (16.3)	29 (20.7)	6.41 (2.69-15.27)	1.86
Positive	A/-	41 (27.9)	79 (56.4)	10.71 (4.92-23.33)	2.37	1.27

A/-: AA + AG; Ala/-: Ala/Val + Ala/Ala.

¹Adjusted for age, sex, OR, 95% CI, β were calculated by logistic regression. HC: Healthy control; GC: Gastric cancer.