Alanine aminotransferase is an inadequate surrogate marker for detecting lamivudine resistance

Table 2 Multivariate analysis of baseline characteristics between patients with and without lamivudine resistance

	Adjusted P value	Adjusted OR (95% CI)
Male	0.842	1.080 (0.506-2.307)
Chinese	0.343	2.099 (0.454-9.707)
Mean age, yr	0.448	0.989 (0.960-1.018)
Cirrhosis	0.977	1.011 (0.479-2.133)
Baseline bilirubin, μmol/L	0.457	0.996 (0.984-1.007)
Baseline albumin, g/L	0.108	0.950 (0.893-1.011)
Baseline ALT, U/L	0.099	0.997 (0.994-1.000)
Baseline AST, U/L	0.521	1.001 (0.998-1.005)
HBeAg positive	0.005	2.857 (1.383-5.903)
Baseline log HBV DNA, IU/mL	0.014	1.415 (1.073-1.865)
Baseline abnormal ALT	0.923	0.959 (0.405-2.27)

Baseline hepatitis B virus (HBV) DNA and hepatitis B "e" antigen (HBeAg) status were independent predictors of lamivudine resistance. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.