Germline mutation analysis of hPMS2 gene in Chinese families with hereditary nonpolyposis colorectal cancer

Figure 1 Missense germline mutation of exon 11 of hPMS2 gene in the proband of H13 hereditary nonpolyposis colorectal cancer kindreds. A: The forward sequence; B: The reverse sequence. Arrow indicates the mutation site, the single basyl substitution was transversed from C to T (C>T) at the codon 511, the codon from ACG to ATG, causing the amiod acid changes from Thr>Met, the change was identified as a new single nucleotide polymorphism.