Portal vein ligation accelerates tumor growth in ligated, but not contralateral lobes

Figure 2 Hepatocyte proliferation after portal vein ligation. A: Hepatocyte proliferation was determined by immunohistochemical staining for proliferating cell nuclear antigen (PCNA). Original magnification was 200 ×; B: Quantitative analysis of PCNA labeling. PCNA labeling index was expressed as percentage of positive nuclei of 400-600 hepatocytes from the 4-6 highest positive fields at high power (400 ×). Data are mean ± SE with n = 4-6 per group. ^aP < 0.05 vs PVL-non-ligated; ^cP < 0.05 vs partial hepatectomy.