Original Article
Copyright ©2010 Baishideng.
World J Gastroenterol. Aug 7, 2010; 16(29): 3664-3673
Published online Aug 7, 2010. doi: 10.3748/wjg.v16.i29.3664
Table 2 Differentially expressed proteins in varioliform gastritis
ID No.Protein nameGene nameAccessionNo.Mass (Da)/pICover rate (mean, %)MascotscoresIntensity of candidateprotein spotsa (positive rate)General function/comments
Up-regulated proteins
1Thioredoxin domain containing protein 5 precursorTXNDC5Q8NBS947 629.2/5.32522836.5 ± 3.1, 2.7 ± 0.4 (100%, 44.4%)Controlling the oxidative protein folding in endoplasmic reticulum
2Proliferating cell nuclear antigenPCNAP1200428 762.4/4.73718418.6 ± 4.2, 3.3 ± 0.9 (94.4%, 70.5%)Cell growth and maintenance
340S ribosomalprotein SARPSAP0886532 702.4/4.794610464.3 ± 11.1, 11.5 ± 2.8 (100%, 88.3%)Originally known as laminin receptor precursor and p40
4Heat-shock protein β-1HSPB1P0479222 768.5/5.93373.8 ± 13.4, 12.7 ± 3.4 (100%, 100%)A HSP27 isoform (pI5.68)
5Inorganic pyrophosphatase2PPA2Q9H2U235 472/5.96924524.1 ± 2.7, 3.6 ± 1.2 (94.4%, 58.9%)Overexpressed in some cancer tissues
6S100 calcium-binding protein A10S100A10P6090311 195.5/6.86214843.0 ± 5.7, 5.9 ± 2.7 (88.9%, 41.2%)It may function as a regulator of protein phosphorylation in the ANXA2 monomer
7Nucleoside diphosphate kinase ANME1P1553117 137.7/5.84919359.4 ± 12.6, 13.2 ± 5.8 (82.4%, 70.6%)It plays a major role in the synthesis of nucleoside triphosphates other than ATP
8Proteasome activator complex subunit 1PSME1Q0632338 966.2/7.65313883.8 ± 17.4, 10.5 ± 4.7 (100%, 41.2%)Implicated in immuno-proteasome assembly and required for efficient antigen processing
9Ubiquitin thiolesterase L3UCHL3P1537426 337/4.74217462.4 ± 11.9, 13.7 ± 7.1 (88.9%, 29.4%)Ubiquitin-protein hydrolase involved in the processing of both ubiquitin precursors and ubiquitinated proteins
10S100 calcium-binding protein A6S100A6P0670311 732.8/5.67123421.6 ± 5.3, 3.7 ± 1.1 (82.4%, 23.5%)Preferentially expressed when quiescent fibroblasts are stimulated to proliferate
Down-regulated proteins
11Cell division cycle 2-like protein kinase 5CDC2L5Q1400448 212.2/8.3371681.7 ± 0.5, 14.2 ± 2.6 (17.6%, 52.9%)May be a controller of the mitotic cell cycle involved
12BTG3 proteinBTG3Q1420129 117.3/9.1642655.8 ± 2.3, 47.4 ± 6.1 (29.4%, 82.4%)Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase
13Neuropolypeptide h3PEBP1P3008631 270.6/5.7582202.9 ± 1.4, 58.6 ± 11.8 (17.6%, 100%)Binds ATP, opioids and phosphatidylethanolamine
14Heat-shock protein 17 kDaHSPB3Q1298816 966/5.73910516.8 ± 4.4, 89.5 ± 14.7 (100%, 100%)Inhibitor of actin polymerization
15Caspase-5 precursorCASP5P5187847 815/9.2482017.6 ± 2.6, 45.9 ± 11.7 (41.2%, 77.8%)Mediator of apoptosis
16Cytokeratin 20KRT20P3590048 487/4.9521312.9 ± 0.4, 17.5 ± 3.6 (29.4%, 52.9%)It plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, it plays a role in the secretion of mucin in the small intestine
17Eukaryotic translation initiation factor 3 subunit 2EIF3IQ1334723 354/4.9441738.9 ± 2.3, 46.3 ± 17.2 (35.3%, 100%)Binds to the 40S ribosome and promotes the binding of methonyl
18Ribosomal protein S12RPS12P2539814 526.0/5.6561415.7 ± 1.4, 52.6 ± 10.3 (29.4%, 70.6%)Belongs to the ribosomal protein S12e family