Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial

doi:10.3748/wjg.v16.i25.3133

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Jul 7, 2010 (publication date) through Sep 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2010; 16(25): 3133-3143
Published online Jul 7, 2010. doi: 10.3748/wjg.v16.i25.3133

Table 3 Efficacy in the ITT population

Characteristic	FOLFOX6 plus cetuximab (arm A, n = 77)	FOLFIRI plus cetuximab (arm B, n = 74)
PFS
Events, n (%)	61 (79)	59 (80)
Median¹, mo (95% CI)	8.6 (6.3-9.7)	8.3 (7.4-8.7)
Log rank P-value	0.7375
Hazard ratio (95% CI)	1.06 (0.74-1.52)
PFS rate¹, % (95% CI)
3 mo	92 (85-98)	78 (68-88)
6 mo	69 (58-80)	69 (58-80)
9 mo	45 (33-58)	34 (23-46)
12 mo	18 (8-27)	18 (8-27)
Overall survival
Events, n (%)	54 (70)	50 (68)
Median¹, mo (95% CI)	17.4 (14.9-22.6)	18.9 (14.7-23.9)
Logrank P-value	0.9230
Hazard ratio² (95% CI)	0.98 (0.67-1.44)
Survival rate¹, % (95% CI)
9 mo	79 (70-88)	79 (70-89)
12 mo	70 (60-80)	71 (60-81)
18 mo	46 (35-57)	53 (42-65)
24 mo	33 (22-44)	38 (26-50)
Best overall response, n (%)
CR	2 (3)	6 (8)
PR	31 (40)	27 (36)
SD	31 (40)	24 (32)
PD	6 (8)	9 (12)
NE	7 (9)	8 (11)
Objective response rate, n (%)	33 (43)	33 (45)
95% CI	32-55	33-57
Odds ratio (95% CI)	0.93 (0.49-1.77)

¹Median time and rates are based on Kaplan-Meier estimates;

²Hazard ratio and corresponding 95% CI based on unadjusted Cox proportional hazard model: hazard rate FOLFIRI plus cetuximab divided by hazard rate FOLFOX6 plus cetuximab. CR: Complete response; NE: Not evaluable; PD: Progressive disease; PFS: Progression-free survival; PR: Partial response; SD: Stable disease.

Citation: Ocvirk J, Brodowicz T, Wrba F, Ciuleanu TE, Kurteva G, Beslija S, Koza I, Pápai Z, Messinger D, Yilmaz U, Faluhelyi Z, Yalcin S, Papamichael D, Wenczl M, Mrsic-Krmpotic Z, Shacham-Shmueli E, Vrbanec D, Esser R, Scheithauer W, Zielinski CC. Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial. World J Gastroenterol 2010; 16(25): 3133-3143
URL: https://www.wjgnet.com/1007-9327/full/v16/i25/3133.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i25.3133