Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis

Table 4 Genotypic frequencies of the VDR FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) polymorphisms in liver cirrhosis patients grouped according to the presence or absence of HCC

VDR	HCC absent (n = 160)	HCC present (n = 80)	OR	95% CI	P1
	F/F = 69 (43.1)	F/F = 36 (45.0)	1	Ref.
FokI	F/f = 73 (45.6)	F/f = 36 (45.0)	0.945	0.537-1.663	NS
	f/f = 18 (11.3)	f/f = 8 (10.0)	0.852	0.345-2.113	NS
	B/B = 28 (17.5)	B/B = 12 (15.0)	1	Ref.	2
BsmI	B/b = 87 (54.4)	B/b = 35 (43.8)	0.939	0.433-2.028	NS
	b/b = 45 (28.1)	b/b = 33 (41.2)	1.711	0.766-3.813	NS
	A/A = 53 (33.1)	A/A = 27 (33.8)	1	Ref.
ApaI	A/a = 85 (53.1)	A/a = 38 (47.5)	0.878	0.483-1.595	NS
	a/a = 22 (13.8)	a/a = 15 (18.7)	1.338	0.605-2.968	NS
	T/T = 44 (27.5)	T/T = 32 (40.0)	1	Ref.	3
TaqI	T/t = 88 (55.0)	T/t = 38 (47.5)	0.594	0.329-1.072	0.08
	t/t = 28 (17.5)	t/t = 10 (12.5)	0.491	0.212-1.141	0.09

The odds ratios were constructed with the wild type for each polymorphism as the reference. The statistical analysis was carried out using the Pearson χ² test.

¹Pearson χ² test;

²B/B + B/b genotypes vs b/b genotype: P < 0.05;

³T/t + t/t genotypes vs T/T genotype: P < 0.05.