Clinicopathological features and prognosis assessment of extranodal follicular dendritic cell sarcoma

Figure 3 Atypical morphology of FDC sarcoma (A-D) and expression of p53 protein (E) and Epstein-Barr virus-encoded RNA (EBER) (F) in tumor cells. A-D: Epithelioid (A and B) and pleomorphic tumor cells (C and D) are arranged in a sheet-like or diffuse pattern. Lymphocyte infiltration is less prominent (A and B) or absent (C and D) in these areas. HE: A, C and D, × 400; B, × 200; E: Nuclear immunoreactivity for p53 protein in majority of tumor cells. S-P, × 400; F: In situ hybridization signal for EBER in tumor cells, × 400.