High-dose vs low-dose proton pump inhibitors for upper gastrointestinal bleeding: A meta-analysis

Table 3 Proton pump inhibitor regimen of the included studies

Author	Arm	Endoscopic therapy	Schedule of the PPIs
Andriulli et al[16]	High	Epinephrine injection or thermal or mechanical therapy	OME or PAN 80 mg iv bolus, 8 mg/h infusion × 3 d
	Low		OME or PAN 40 mg iv bolus 24 h × 3 d
Yüksel et al[17]	High	Epinephrine injection and thermal therapy	PAN 80 mg iv bolus, 8 mg/h infusion × 3 d
	Low		PAN 40 mg iv bolus Q12 h × 3 d
Hung et al[2]	High	Epinephrine injection or thermal therapy	PAN 80 mg iv bolus, 8 mg/h infusion × 3 d
	Low		PAN 80 mg iv bolus, 40 mg iv bolus Q12 h × 3 d
Lin et al[19]	High	Epinephrine injection	OME 40 mg infusion Q6 h × 3 d
	Low		OME 40 mg infusion Q12 h × 3 d
Cheng et al[21]	High	Epinephrine injection or thermal therapy	OME 80 mg iv bolus, 200 mg infusion 24 h × 3 d
	Low		OME 80 mg iv bolus, 80 mg infusion 24 h × 3 d
Dokas et al[9]	High	Epinephrine injection or mechanical therapy	OME 80 mg iv bolus, 160 mg infusion Q24 h × 3 d
	Low		OME 40 mg iv bolus Q12 h × 3 d
Chilovi et al[24]	High	NA	PAN 80 mg iv bolus, 40 mg iv bolus Q8 h
	Low		OME 80 mg iv bolus, 40 mg
Udd et al[8]	High	Epinephrine injection or thermal or mechanical therapy	OME 80 mg iv bolus, 8 mg/h infusion × 3 d
	Low		OME 20 mg iv bolus 24 h × 3 d
Schonekas et al[7]	High	NA	PAN 40 mg iv bolus 8 mg/h infusion × 3 d
	Low		PAN 40 mg iv bolus Q24 h × 3 d

PPIs: Proton pump inhibitors; OME: Omeprazole; PAN: Pantoprazole.