Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients

Table 6 Genotype-specific CD odds ratios¹ (with 95% CI) for combinations of variants in IBD5 and CARD15

	CARD15 R702W		CARD15 G908R		CARD15 L1007fs		CARD15 status
	CC	CT+TT	GG	GC+CC	- -	- insC+insC insC	-	+
IGR2198a_1
GG	1	3.17 (1.15-8.69)a	1	1.79 (0.39-8.22)	1	3.04 (1.30-7.14)a	1	2.65 (1.36-5.17)a
GC+CC	1.60 (1.13-2.27)a	2.819 (1.39-5.72)a	1.52 (1.08-2.13)a	2.69 (0.97-7.45)	1.61 (1.13-2.31)a	3.58 (1.80-7.16)a	1.63 (1.11-2.39)a	3.19 (1.90-5.37)a
IGR2096a_1
GG	1	3.07 (1.20-7.86)a	1	2.19 (0.51-9.41)	1	2.43 (1.06-5.59)a	1	2.46 (1.29-4.69)a
GT+TT	1.55 (1.09-2.20)a	2.75 (1.32-5.70)a	1.47 (1.05-2.06)a	2.41 (0.86-6.77)	1.48 (1.03-2.11)a	3.74 (1.85-7.54)a	1.54 (1.05-2.26)a	3.18 (1.87-5.39)a

¹IGR2198a_1, IGR2096a_1, CARD15 R702W, G908R and L1007fs: OR relative to wild type genotype; CARD15 status: OR relative to - (wild type) group.

^aP < 0.05 vs controls.