Different profiles of cytokine expression during mild and severe acute pancreatitis

Table 1 Differences in clinical course of mild and severe acute pancreatitis (mean ± SD/count)

Clinical severity scores and patient characteristics	Mild AP	Severe AP	P
Apache II (score)	3.6 ± 1.9	11.6 ± 4.7	< 0.01
Imrie-Glasgow (score)	2.2 ± 1.2	4.4 ± 1.5	< 0.01
MODS (score)	1.1 ± 1.3	4.3 ± 3.4	< 0.01
Necrotizing AP (count)	16	36	< 0.01
C-reactive protein (mg/L)	91.8 ± 18.7	152.9 ± 21.5	< 0.01
Necrosis volume > 30% (count)	8	26	< 0.01
Infectious complications (count)1	2	12	< 0.01
Presence of MOF (count)	0	18	< 0.01
Need for surgery (count)2	1	5	0.06
ICU stay (d)	1.0 ± 1.0	9.0 ± 2.0	< 0.05
Total hospital stay (d)	12.0 ± 1.0	19.0 ± 3.0	< 0.05
Number of early deaths (< 2 wk)	0	9	< 0.01
Number of late deaths (> 2 wk)	0	5	< 0.01

¹Infectious complications: proven sepsis, infected pancreatic necrosis, lung and urinary infection;

²Need for surgery: fasciotomy for intraabdominal compartment syndrome and/or necrosectomy. AP: Acute pancreatitis; MOF: Multiple organ failure; ICU: Intensive care unit.