Freeman HJ. Risk factors in familial forms of celiac disease. World J Gastroenterol 2010; 16(15): 1828-1831
Corresponding Author of This Article
Dr. Hugh James Freeman, MD, CM, FRCPC, FACP, Department of Medicine, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T1W5, Canada. email@example.com
Article-Type of This Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 21, 2010; 16(15): 1828-1831 Published online Apr 21, 2010. doi: 10.3748/wjg.v16.i15.1828
Risk factors in familial forms of celiac disease
Hugh James Freeman
Hugh James Freeman, Department of Medicine, University of British Columbia Hospital, Vancouver, BC V6T1W5, Canada
Author contributions: Freeman HJ contributed all to this paper.
Correspondence to: Dr. Hugh James Freeman, MD, CM, FRCPC, FACP, Department of Medicine, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T1W5, Canada. firstname.lastname@example.org
Telephone: +1-604-8227216 Fax: +1-604-8227236
Received: December 17, 2009 Revised: February 12, 2010 Accepted: February 19, 2010 Published online: April 21, 2010
Celiac disease has been reported in up to 2% of some European populations. A similar risk has been identified in the America and Australia where immigration of Europeans has occurred. Moreover, an increasing number of celiac disease patients are being identified in many Asian countries, including China and India. Finally, celiac disease has also been detected in Asian immigrants and their descendants to other countries, such as Canada. Within these so-called “general” celiac populations, however, there are specific high risk groups that have an even higher prevalence of celiac disease. Indeed, the single most important risk factor for celiac disease is having a first-degree relative with already-defined celiac disease, particularly a sibling. A rate up to 20% or more has been noted. Risk is even greater if a specific family has 2 siblings affected, particularly if a male carries the human leukocyte antigen-DQ2. Both structural changes in the small bowel architecture occur along with functional changes in permeability, even in asymptomatic first-degree relatives. Even if celiac disease is not evident, the risk of other autoimmune disorders seems significantly increased in first-degree relatives as well as intestinal lymphoma. Identification of celiac disease is important since recent long-term studies have shown that the mortality of celiac disease is increased, if it is unrecognized and untreated.
Citation: Freeman HJ. Risk factors in familial forms of celiac disease. World J Gastroenterol 2010; 16(15): 1828-1831
Only a few decades ago, celiac disease was considered an uncommon disorder present mainly in Europe or in countries where Europeans had emigrated, including Canada and Australia. In Ireland, and in particular, Galway in the West of Ireland, appears to have an especially high prevalence of celiac disease with an estimate of up to 1 in 300 persons. Similar experiences have been noted in Scandinavian countries. In the United States, however, earlier reports suggest that the detection of celiac disease is surprisingly low[1,3]. With the emergence of modern serological screening tests for celiac disease and increased efforts to use these screening measures, celiac disease has become more readily detectable.
EMERGING RISK ESTIMATES
In recent years, changes have occurred with an estimate of overall prevalence rates increased in most countries, often in the region of about 1%-2%. Interestingly, in a longitudinally-based study from Olmstead County in the United States over many decades, increased detection has been reported, in part, due to increased use of serological screening. Recently, a report from Hangzhou in China has also suggested that the prevalence of adult celiac disease may be more common in China than previously appreciated. Of note, celiac disease has also been reported in immigrants to Canada from China, Japan and South Asia, particularly from the Punjab region of India. Even in the United States, celiac disease is now generally believed to affect 0.5%-1.0% of the general population.
HIGH RISK GROUPS FOR CELIAC DISEASE
These reported numbers often reflect prevalence estimates, usually resulting from screening of selected groups, e.g. blood bank serum samples, thought to be representative of the entire population from a specific geographic area. Confirmatory small intestinal biopsies have often been done in sero-positive cases to provide an overall “minimal” estimate of population prevalence (since all sero-positive patients may not be available for biopsy). As shown in Table 1, there are also some high risk groups within the general celiac population, often without typical clinical symptoms, such as diarrhea or weight loss, that may have even higher prevalence rates. Among these factors that specifically denote a higher risk for celiac disease, the single most important is a familial history of biopsy-defined celiac disease with some estimates up to 20% or more of first-degree relatives. Diagnosis of celiac disease in all of these high risk groups, however, is especially important since failure to detect celiac disease coupled with failure to treat the disease may lead to an increased morbidity, and critically, a nearly 4-fold increased risk of mortality from celiac disease.
Evidence for a familial risk in celiac disease has been accumulated from many sources (Table 2), including biopsy and serological studies in families with known celiac disease[10-17], animal model studies in the Irish Setter dog[18,19], functional studies based on evaluation of intestinal permeability or other absorptive indices[20-23], human leukocyte antigen (HLA)-genotyping studies[24-26], and more recently, genome-wide expression and linkage studies.
Early family studies using small intestinal biopsies have provided strong evidence for the familial nature of celiac disease[10,11]. A systematic review of these earlier studies using MEDLINE and EMBASE databases concluded that up to 20% of first-degree relatives of European descent may be at risk for celiac disease. Similar results have been reported from non-European populations, including a recent report from the Punjab region of India. In addition, more extensive studies in biopsy-defined celiac disease have further confirmed these findings, particularly in “at-risk” first-degree (1:22) and second-degree relatives (1:39), compared to a control “not-at-risk” group (1:133). This risk appears to be especially increased in families with at least 2 siblings diagnosed as celiac disease, and in this setting, more males were detected compared to females. Particularly significant predictors of familial risk include carrying HLA-DQ2 and being a sibling of the proband.
Animal model studies
Animal studies have provided some indirect, but important evidence. Gluten-sensitive enteropathy has been reported in a family of Irish Setter dogs along with the association of a canine major histocompatibility complex (MHC) DQ haplotype.
Earlier studies showed that an intentional increase in gluten intake may provoke jejunal mucosal architectural changes in some first-degree relatives along with reduced xylose absorption, even in those without clinically overt disease, suggesting that, in the genetically-predisposed, both structural and functional changes may be induced in familial celiac disease. Abnormal permeability to lactulose and mannitol in first-degree relatives also suggests that functional changes may occur in biopsy-defined disease as well as in first-degree relatives with apparently normal small bowel biopsies. Importantly, this familial risk in first-degree relatives is genetically-based and not related to their daily calculated gluten intake. In other words, familial celiac disease is not due to a common environment with increased intake of gluten-containing foods, but has a definitive genetic basis.
Human leukocyte antigen marker studies
HLA markers have been popularly used for decades in clinical studies of celiac disease. These clinical studies have served to emphasize the strong genetic component involved in the development of celiac disease. In large part, possession of the HLA-DQ2 variant, necessary for presentation of dietary antigens to intestinal T-cells, is critical. Non-HLA genetic factors are also increasingly recognized as a very important, and possibly even a more significant and critical risk factor in the development of familial celiac disease. Furthermore, a recent HLA-genotyping study (i.e. DQA1*0501, DQB1*0201, DRB1*04) with small bowel biopsies from Finland has suggested a practical means of exclusion of some first-degree relatives without celiac disease for screening purposes. However, it has been reported that some asymptomatic first-degree relatives may show only minimal changes in intra-epithelial lymphocyte numbers. In addition, with a prolonged follow-up, flat small bowel mucosal biopsies have been reported in familial disease without initially abnormal biopsies. These findings are important and need to be confirmed as further longitudinal studies may be required in first-degree relatives without initial biopsy evidence of celiac disease.
Most exciting are the recent genome-wide expression and genome-wide linkage studies done to explore a number of clinical disorders, including celiac disease. A recent meta-analysis of 8 genome-wide linkage studies in celiac disease permitted definition of both HLA and non-HLA chromosome regions that appear to predispose to celiac disease and suggested the possibility of different types of disease-predisposing variants.
RISK OF ASSOCIATED DISEASE IN RELATIVES
Of potentially even greater significance are reports on relatives without celiac disease at risk for other diseases, often associated with celiac disease. For example, a serological survey study of first-degree relatives of children with documented celiac disease suggested that autoimmune diseases may be increased in addition to biopsy-defined, but “sub-clinical” celiac disease. In addition, first-degree relatives may also develop the closely linked dermatological disorder, dermatitis herpetiformis. Moreover, patients with type-1 diabetes have an increased risk of celiac disease and biopsy-defined, but essentially asymptomatic and unrecognized celiac disease. Finally, although lymphoma risk seems to have fallen in the past 4 decades, individuals with a sibling affected with celiac disease have an increased lymphoma risk. These studies, then, have important implications for risk of familial forms of celiac disease in relatives, particularly first-degree, but also for a host of other genetically-related clinical disorders, even in the absence of celiac disease. In future, expression of different celiac disease phenotypes and their individual specific risks of different diseases may be more readily defined with precise genetic markers or more precise genetic signatures.
Lohi S, Mustalahti K, Kaukinen K, Laurila K, Collin P, Rissanen H, Lohi O, Bravi E, Gasparin M, Reunanen A. Increasing prevalence of coeliac disease over time.Aliment Pharmacol Ther. 2007;26:1217-1225.
Murray JA, Van Dyke C, Plevak MF, Dierkhising RA, Zinsmeister AR, Melton LJ 3rd. Trends in the identification and clinical features of celiac disease in a North American community, 1950-2001.Clin Gastroenterol Hepatol. 2003;1:19-27.
Jiang LL, Zhang BL, Liu YS. Is adult celiac disease really uncommon in Chinese?J Zhejiang Univ Sci B. 2009;10:168-171.
Dubé C, Rostom A, Sy R, Cranney A, Saloojee N, Garritty C, Sampson M, Zhang L, Yazdi F, Mamaladze V. The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review.Gastroenterology. 2005;128:S57-S67.
Gautam A, Jain BK, Midha V, Sood A, Sood N. Prevalence of celiac disease among siblings of celiac disease patients.Indian J Gastroenterol. 2006;25:233-235.
Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S, Elitsur Y, Green PH, Guandalini S, Hill ID. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study.Arch Intern Med. 2003;163:286-292.
Book L, Zone JJ, Neuhausen SL. Prevalence of celiac disease among relatives of sib pairs with celiac disease in U.S. families.Am J Gastroenterol. 2003;98:377-381.
Gudjónsdóttir AH, Nilsson S, Ek J, Kristiansson B, Ascher H. The risk of celiac disease in 107 families with at least two affected siblings.J Pediatr Gastroenterol Nutr. 2004;38:338-342.
Rubio-Tapia A, Van Dyke CT, Lahr BD, Zinsmeister AR, El-Youssef M, Moore SB, Bowman M, Burgart LJ, Melton LJ 3rd, Murray JA. Predictors of family risk for celiac disease: a population-based study.Clin Gastroenterol Hepatol. 2008;6:983-987.
Daminet SC. Gluten-sensitive enteropathy in a family of Irish setters.Can Vet J. 1996;37:745-746.
Polvi A, Garden OA, Elwood CM, Sørensen SH, Batt RM, Mäki M, Partanen J. Canine major histocompatibility complex genes DQA and DQB in Irish setter dogs.Tissue Antigens. 1997;49:236-243.
Doherty M, Barry RE. Gluten-induced mucosal changes in subjects without overt small-bowel disease.Lancet. 1981;1:517-520.
Vogelsang H, Wyatt J, Penner E, Lochs H. Screening for celiac disease in first-degree relatives of patients with celiac disease by lactulose/mannitol test.Am J Gastroenterol. 1995;90:1838-1842.
van Elburg RM, Uil JJ, Mulder CJ, Heymans HS. Intestinal permeability in patients with coeliac disease and relatives of patients with coeliac disease.Gut. 1993;34:354-357.
van Overbeek FM, Uil-Dieterman IG, Mol IW, Köhler-Brands L, Heymans HS, Mulder CJ. The daily gluten intake in relatives of patients with coeliac disease compared with that of the general Dutch population.Eur J Gastroenterol Hepatol. 1997;9:1097-1099.
Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, Kosma VM, Naukkarinen A, Laakso M. HLA genotyping is useful in the evaluation of the risk for coeliac disease in the 1st-degree relatives of patients with coeliac disease.Scand J Gastroenterol. 2006;41:1299-1304.
Vazquez H, Cabanne A, Sugai E, Fiorini A, Pedreira S, Mauriño E, Smecuol E, Dezi R, Niveloni S, Valero J. Serological markers identify histologically latent coeliac disease among first-degree relatives.Eur J Gastroenterol Hepatol. 1996;8:15-21.
Niveloni S, Pedreira S, Sugai E, Vazquez H, Smecuol E, Fiorini A, Cabanne A, Dezi R, Valero J, Kogan Z. The natural history of gluten sensitivity: report of two new celiac disease patients resulting from a long-term follow-up of nonatrophic, first-degree relatives.Am J Gastroenterol. 2000;95:463-468.
Forabosco P, Neuhausen SL, Greco L, Naluai AT, Wijmenga C, Saavalainen P, Houlston RS, Ciclitira PJ, Babron MC, Lewis CM. Meta-analysis of genome-wide linkage studies in celiac disease.Hum Hered. 2009;68:223-230.
Cataldo F, Marino V. Increased prevalence of autoimmune diseases in first-degree relatives of patients with celiac disease.J Pediatr Gastroenterol Nutr. 2003;36:470-473.
Hervonen K, Hakanen M, Kaukinen K, Collin P, Reunala T. First-degree relatives are frequently affected in coeliac disease and dermatitis herpetiformis.Scand J Gastroenterol. 2002;37:51-55.
Hummel M, Bonifacio E, Stern M, Dittler J, Schimmel A, Ziegler AG. Development of celiac disease-associated antibodies in offspring of parents with type I diabetes.Diabetologia. 2000;43:1005-1011.
Gao Y, Kristinsson SY, Goldin LR, Björkholm M, Caporaso NE, Landgren O. Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial association.Gastroenterology. 2009;136:91-98.