Editorial
Copyright ©2010 Baishideng.
World J Gastroenterol. Apr 21, 2010; 16(15): 1811-1819
Published online Apr 21, 2010. doi: 10.3748/wjg.v16.i15.1811
Table 1 Literature summary on the effect of hepatic macrophage depletion on the extent of liver injury in experimental models of ALF
StudyModelMethod of macrophage depletion/inhibitionAffect on severity of acute liver injuryConclusion
Laskin et al[18], 1995APAP (rat)Gadolinium chloride/dextran sulphateDecreased ALT at 24 h in treated groups; Decreased necrosisMacrophage depletion was protective
Michael et al[19], 1999APAP (mouse)Gadolinium chloride/dextran sulphateDecreased ALT at 8 h in treated groupsMacrophage depletion was protective
Hogaboam et al[12], 2000APAP (mouse)CCR2 -/-ALT at 24 and 48 h, hepatic necrosis and TUNEL staining all increased in KO; Increase in IFN-γ and TNF-αCCR2 KO - macrophage depletion worsened liver injury
Dambach et al[13], 2002APAP (mouse)CCR2 -/-ALT levels similar in WT and KO mice; Histologically KO mice showed less inflammation at 72 hCCR2 KO - macrophage depletion, caused less inflammation at 72 h but no overall difference in outcome
Ju et al[20], 2002APAP (mouse)Liposome/clodronateIncreased ALT at 8 and 24 h in treated groupMacrophage depletion increased liver damage
Holt et al[6], 2008APAP (mouse)CCR2 -/-ALT same at 10 and 24 h; Comparable histological necrosis at 24 h but delayed recovery at 48 and 72 h in CCR2 -/-Reduction in infiltrating macrophage population causes delayed recovery
Karlmark et al[5], 2009CCl4 (mouse)Liposome/clodronateUnaltered ALT level at 4 and 24 h post-CCl4Reduction in infiltrating macrophages had no effect on severity of liver damage