Clinicopathological significance and prognostic value of LRP16 expression in colorectal carcinoma

Table 1 Correlation between LRP16 expression and clinicopathological factors in colorectal cancer n (%)

Variables	LRP16		Statistical value
	Positive group (n = 197)	Negative group (n = 139)
Gender
Male	78 (61.4)	49 (38.6)	χ2 = 1.460a
Female	39 (52.7)	35 (47.3)	P = 0.227
Age (yr)
< 45	20 (64.5)	11 (35.5)	χ2 = 0.640a
45 ≤n < 60	36 (58.0)	26 (42.0)	P = 0.726
≥ 60	61 (56.5)	47 (43.5)
Tumor size (cm)
d < 5	68 (50.0)	68 (50.0)	χ2 = 13.604a
5 ≤ d < 10	42 (72.4)	16 (27.6)	P = 0.001
d ≥ 10	7 (100.0)	0 (0.0)
Tumor location
Cecum	5 (55.6)	4 (44.4)	χ2 = 6.027a
Ascending colon	22 (75.9)	7 (24.1)	P = 0.304
Transverse colon	8 (57.1)	6 (42.9)
Descending colon	6 (66.7)	3 (33.3)
Sigmoid colon	29 (60.4)	19 (39.6)
Rectum	47 (51.1)	45 (48.9)
Histologic differentiation
Well differentiated	12 (50.0)	12 (50.0)	χ2 = 9.210a
Moderately differentiated	56 (50.9)	54 (49.1)	P = 0.010
Poorly differentiated	49 (73.1)	18 (226.9)
Depth of invasion, T stage
T1	2 (28.6)	5 (71.4)	χ2 = 25.470a
T2	25 (36.8)	43 (63.2)	P = 0.001
T3	79 (69.9)	34 (30.1)
T4	11 (84.6)	2 (15.4)
Lymph node metastasis
LN = 0	58 (45.3)	70 (54.7)	χ2 = 24.735a
LN = 1-3	43 (78.2)	12 (21.8)	P = 0.001
LN > 3	16 (88.9)	2 (11.1)
Distant metastasis
Negative	107 (56.3)	83 (43.7)	χ2 = 5.115a
Positive	10 (90.9)	1 (9.1)	P = 0.027
TNM stage
I-II	52 (43.3)	68 (57.7)	χ2 = 27.088a
III-IV	65 (80.2)	16 (19.8)	P = 0.001

^aP < 0.05, statistically significant. LRP16: Leukemia related protein 16.