Comparative study of omeprazole, lansoprazole, pantoprazole and esomeprazole for symptom relief in patients with reflux esophagitis

Figure 4 Daily changes in mean heartburn score for all subjects on each proton pump inhibitor regimen, considering only subjects with symptoms prior to commencement of test-drug administration. (◆) Subjects administered omeprazole (n = 61), (■) Subjects administered lansoprazole (n = 63), (▲) Subjects administered pantoprazole (n = 62), (●) Subjects administered esomeprazole (n = 63). △1-5 significant difference between the omeprazole, lansoprazole, pantoprazole and esomeprazole after 1-5 d drug administration, P = 0.0018, 0.0020, 0.0006, respectively, P = 0.0098, 0.0046, 0.0005, respectively, P = 0.0027, 0.0037, 0.0009, respectively, P = 0.0137, 0.0016, 0.0031, respectively, P = 0.0069, 0.0076, 0.0119, respectively.