Genetic polymorphisms in non-alcoholic fatty liver disease: Clues to pathogenesis and disease progression

Table 1 Studies of genetic polymorphisms in non-alcoholic fatty liver disease (NAFLD) included

Gene	Polymorphism	Ref.	No. of patients with NAFLD included in the study
Peroxisome proliferator-activated receptor γ coactivator 1α (PPARGC1A)	rs2290602	Yoneda et al[16], 2008	115
	Gly482Ser	Hui et al[17], 2008	96
Microsomal triglyceride transfer protein (MTTP)	-493G/T	Namikawa et al[18], 2004	63
		Gambino et al[19], 2007	29
Human leptin receptor	G3057A	Lu et al[24], 2009	104
Adiponectin	45G/T and 276G/T	Musso et al[28], 2008	70
Hepatic lipase	-514C/T	Zhan et al[29], 2008	106
Phosphatidylethanolamine N-methyltransferase (PEMT)	Val175Met	Song et al[31], 2005	28
		Dong et al[32], 2007	107
Methylenetetrahydrofolate reductase (MTHFR)	C677T and A1298C	Sazci et al[33], 2008	57
Tumor necrosis factor-α (TNF-α)	-238 and -308	Valenti et al[38], 2002	99
	-1031, -863, -857, -308 and -238	Tokushige et al[39], 2007	102
Angiotensinogen	G-6A	Dixon et al[45], 2003	105
Transforming growth factor-β1 (TGF-β1)	Pro25Arg