Brief Article
Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Dec 21, 2009; 15(47): 5992-5999
Published online Dec 21, 2009. doi: 10.3748/wjg.15.5992
Table 3 Twelve-hour pharmacokinetic parameters of DCQD components in rats of the two groups (n = 6)
T1/2α (h)CL/F (L∙h per kg)AUC(0-∞) (μg/L per hour)MRT(0-t) (h)Tmax (h)Cmax (μg/L)
Rhein
Sham0.33 ± 0.134.03 ± 1.384720 ± 15148.86 ± 0.620.36 ± 0.11510 ± 283
AP4.367 ± 2.330.133 ± 0.062870 ± 5637.82 ± 3.371.75 ± 1.25479 ± 126
t4.27216.91062.80540.75132.72420.2448
P0.001600.01860.46980.02140.8116
Rheochrysidin
Sham0.354 ± 0.3020.356 ± 0.1416.047 ± 6.084.189 ± 0.4630.569 ± 0.263.86 ± 1.09
AP1.464 ± 0.4490.328 ± 0.10916.63 ± 5.064.34 ± 0.291.5 ± 0.552.58 ± 0.58
t5.02470.38660.1790.69293.75972.5511
P0.00050.70720.86150.50410.00370.0288
Chrysophanol
Sham0.38 ± 0.2724.32 ± 9.65461.3 ± 188.78.49 ± 0.930.59 ± 0.2453.02 ± 21.9
AP0.89 ± 0.480.095 ± 0.035115.8 ± 34.8910 ± 5.11.33 ± 0.5217.59 ± 10.5
t2.26836.09944.39650.70883.1653.4855
P0.04670.00010.00130.49470.01010.0059