Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components

Table 1 Parameters of the 6 major DCQD components in rat plasma QC samples (%, n = 6)

	Spiked amount (ng/mL)	Intra-day		Inter-day		Extract
		RSD	Ac	RSD	Ac	Recovery	RSD
Rhein	39.1	3.76	104.60	3.53	107.94	104.60	3.76
	156	5.55	100.32	5.52	106.87	100.32	5.55
	625	5.31	101.07	5.56	105.36	101.07	5.31
	3750	4.24	101.24	6.23	98.37	101.24	4.24
Chrysophanol	6.1	2.37	99.4	4.46	98.67	99.39	2.36
	24.4	4.38	104.17	4.88	101.14	104.17	4.37
	97.7	1.64	96.66	3.33	98.09	96.66	1.64
	586	3.78	103.98	4.44	101.13	103.98	3.78
Rheochrysidin	39.1	5.69	97.70	5.72	100.78	97.69	5.68
	156	3.33	99.89	4.13	101.14	99.89	3.33
	625	3.22	105.92	3.73	104.37	105.92	3.22
	3750	4.75	103.07	4.84	103.49	103.07	4.75
Magnolol	6.1	5.51	102.13	5.07	106.33	102.13	5.51
	24.4	2.39	104.78	5.79	99.86	104.78	2.39
	97.7	5.51	107.81	4.92	106.23	102.47	5.51
	586	3.77	105.97	5.33	105.29	105.97	3.77
Hesperidin	6.1	4.12	95.96	4.82	98.49	95.96	4.12
	24.4	5.83	99.52	5.10	100.29	99.52	5.83
	97.7	4.21	100.14	3.95	99.72	100.16	4.21
	586	2.77	97.13	4.91	98.52	97.13	2.76
Naringin	6.1	2.66	95.66	4.26	99.29	95.67	2.657
	24.4	2.82	102.46	3.95	103.37	102.45	2.82
	97.7	3.81	100.78	3.96	100.66	100.78	3.81
	586	5.24	98.27	5.59	99.32	98.27	5.24

DCQD: Da-Cheng-Qi Decoction; QC: Quality control.