Polymorphisms of some cytokines and chronic hepatitis B and C virus infection

Table 6 Polymorphisms of IL-2-330, IFN-γ+874, IL-4 -589 and IL-10-1082 and -592 and HCV RNA and ALT level n (%)

	HCV RNA -	HCV RNA +	χ2	P	ALT < 80 U/L	ALT ≥ 80 U/L	χ2	P
IL-2-330
TT	29 (37.2)	39 (37.1)			102 (41.8)	11 (33.3)
GG	14 (17.9)	14 (13.3)	0.83	0.66	35 (14.3)	4 (12.1)	1.35	0.51
TG	35 (44.9)	52 (49.5)			107 (43.9)	18 (54.5)
T	93 (59.6)	130 (61.9)	0.20	0.66	311 (63.7)	40 (60.0)	0.24	0.62
G	63 (40.4)	80 (38.1)			177 (36.3)	26 (39.4)
IFN-γ+874
TT	13 (16.7)	10 (9.5)			29 (11.9)	3 (9.1)
AA	28 (35.9)	45 (42.9)	2.36	0.31	85 (34.8)	12 (36.4)	0.23	0.89
TA	37 (47.4)	50 (47.6)			130 (53.3)	18 (54.5)
T	63 (40.4)	70 (33.3)	1.92	0.17	188 (38.5)	24 (36.4)	0.12	0.74
A	93 (59.6)	140 (66.7)			300 (61.5)	42 (63.6)
IL-10-1082
GG	1 (1.3)	2 (1.9)			3 (1.2)	0 (0.0)
AA	14 (17.9)	44 (41.9)	12.27	0.00	81 (33.2)	16 (48.5)	3.25	0.20
GA	63 (80.8)	59 (56.2)			160 (65.6)	17 (51.5)
G	91 (58.3)	147 (70.0)	5.36	0.02	166 (34.0)	17 (25.8)	1.79	0.18
A	65 (41.7)	63 (128)			322 (66.0)	49 (74.2)
IL-10-592
AA	41 (52.6)	44 (41.9)			110 (45.1)	8 (24.2)
CC	6 (7.7)	11 (10.5)	2.10	0.35	27 (11.1)	3 (9.1)	6.32	0.04
AC	31 (39.7)	50 (47.6)			107 (43.9)	22 (66.7)
A	113 (72.4)	138 (65.7)	1.88	0.17	327 (67.0)	38 (57.6)	2.30	0.09
C	43 (27.6)	72 (34.3)			161 (33.0)	28 (42.4)
IL-4-589
CC	3 (3.8)	5 (4.8)			6 (2.5)	3 (9.1)
TT	48 (61.5)	55 (52.4)	1.53	0.47	132 (54.1)	8 (24.2)	12.46	0.02
CT	27 (34.6)	45 (42.9)			106 (43.4)	22 (66.7)
C	33 (21.2)	55 (26.2)	1.24	0.27	118 (24.2)	28 (42.4)	9.97	0.00
T	123 (78.8)	155 (73.8)			370 (75.8)	38 (57.6)