Polymorphisms of some cytokines and chronic hepatitis B and C virus infection

Table 5 Polymorphisms of IL-2-330, IFN-γ+874, IL-4-589, IL-10-1082 and -592 and clinical outcome n (%)

Genotype	Control (n = 74)	Mild CH (n = 122)	Moderate/severe CH (n = 57)	Cirrhosis (n = 24)	χ2	P
IL-2-330
TT	22 (29.7)	54 (44.3)	23 (40.4)	13 (54.2)
GG	19 (25.7)	14 (11.4)	6 (10.5)	1 (4.2)	13.46	0.04
TG	33 (44.6)	54 (44.3)	28 (49.1)	10 (41.7)
T	77 (52.0)	163 (66.8)	74 (64.9)	36 (75.0)	11.69	0.01
G	71 (48.0)	81 (33.2)	40 (35.0)	12 (25.0)
IFN-γ+874
TT	8 (10.8)	14 (11.5)	5 (8.8)	4 (16.7)
AA	14 (18.9)	48 (39.3)	26 (45.6)	9 (37.5)	14.78	0.02
TA	52 (70.3)	60 (49.2)	26 (45.6)	11 (45.8)
T	68 (45.9)	90 (36.9)	36 (31.6)	19 (39.6)	5.68	0.13
A	80 (54.1)	154 (63.1)	78 (68.4)	29 (60.4)
IL-10-1082
GG	1 (1.4)	1 (0.8)	1 (1.8)	0 (0.0)
AA	16 (21.6)	44 (36.1)	24 (42.1)	13 (54.2)	11.40	0.07
GA	57 (77.0)	77 (63.1)	32 (56.1)	11 (45.8)
G	59 (39.9)	79 (32.4)	34 (29.8)	11 (22.9)	5.85	0.12
A	89 (60.1)	165 (67.6)	80 (70.2)	37 (77.1)
IL-10-592
AA	34 (45.9)	51 (41.8)	22 (38.6)	11 (45.8)
CC	9 (12.2)	11 (9.0)	8 (14.0)	2 (8.3)	2.50	0.87
AC	31 (41.9)	60 (49.2)	27 (47.4)	11 (45.8)
A	98 (66.2)	163 (66.8)	71 (62.3)	33 (68.8)	0.92	0.82
C	50 (33.8)	81 (33.2)	43 (37.7)	15 (31.3)
IL-4-589
CC	3 (4.0)	3 (2.4)	3 (5.3)	0 (0.0)
TT	38 (51.4)	69 (54.8)	24 (42.1)	11 (45.8)	4.58	0.60
CT	33 (44.6)	54 (42.9)	30 (52.6)	13 (54.2)
C	39 (26.4)	58 (23.8)	36 (31.6)	13 (27.1)	2.46	0.48
T	109 (73.6)	186 (76.2)	78 (68.4)	35 (72.9)