Polymorphisms of some cytokines and chronic hepatitis B and C virus infection

Table 4 Polymorphisms of IL-2-330, IFN-γ+874, IL-10-1082 and -592 and IL-4-589 and HBV and HCV infection n (%)

Genotype allele	Controls (n = 74)	HCV infection (n = 55)	HBV infection (n = 69)	HBV/HCV coinfection (n = 79)	χ2	P
IL-2-330
TT	22 (29.7)	24 (43.6)	33 (47.8)	34 (43.0)
GG	19 (25.7)	6 (10.9)	4 (5.8)	10 (12.7)	14.24	0.03
TG	33 (44.6)	25 (45.5)	32 (46.4)	35 (44.3)
T	77 (52.0)	73 (66.4)	98 (71.0)	103 (65.2)	12.33	0.01
G	71 (48.0)	37 (33.6)	40 (29.0)	55 (34.8)
IFN-γ+874
TT	7 (9.5)	5 (9.1)	9 (13.0)	11 (13.9)
AA	14 (18.9)	23 (41.8)	25 (36.2)	35 (44.3)	16.15	0.01
TA	53 (71.6)	27 (49.1)	35 (50.7)	33 (41.8)
T	67 (45.3)	37 (33.6)	53 (38.4)	55 (34.8)	4.87	0.18
A	81 (54.7)	73 (66.4)	85 (61.6)	103 (65.2)
IL-10-1082
GG	1 (1.4)	2 (3.6)	0 (0.0)	0 (0.0)
AA	16 (21.6)	21 (38.2)	27 (39.1)	33 (41.8)	13.05	0.04
GA	57 (77.0)	32 (58.2)	42 (60.9)	46 (58.2)
G	59 (39.9)	36 (32.7)	42 (30.4)	46 (29.1)	4.65	0.20
A	89 (60.1)	74 (67.3)	96 (69.6)	112 (70.9)
IL-10-592
AA	34 (45.9)	20 (36.4)	29 (42.0)	35 (44.3)
CC	9 (12.2)	6 (10.9)	9 (13.0)	6 (7.6)	2.83	0.83
AC	31 (41.9)	29 (52.7)	31 (44.9)	38 (48.1)
A	99 (66.9)	69 (62.7)	89 (64.5)	108 (68.4)	1.10	0.78
C	49 (33.1)	41 (37.3)	49 (35.5)	50 (31.6)
IL-4-589
CC	5 (6.8)	1 (1.8)	1 (1.4)	2 (2.5)
TT	38 (51.4)	28 (50.9)	35 (50.7)	39 (49.4)	4.41	0.62
CT	31 (41.9)	26 (47.3)	33 (47.8)	38 (48.1)
C	41 (27.7)	28 (25.5)	35 (25.4)	42 (26.6)	0.26	0.97
T	107 (72.3)	82 (74.5)	103 (74.6)	116 (73.4)