Gastric leptomeningeal carcinomatosis: Multi-center retrospective analysis of 54 cases

Table 6 Survival duration and prognostic factors

Factors	Median OS (mo)	Univariate	Multivariate
Gender
Male	7.1	0.491	-
Female	6.7
Age (yr)
> 60	12.4	0.214	-
≤ 60	6.4
PS (LMC)
0, 1	11.7	0.975	-
≥ 2	6.4
Hb (LMC)
> 11	12.4	0.038	NS
≤ 11	5.7
MRI enhance
Negative	5.7	0.316	-
Positive	7.1
CSF pressure
> 120	6.4	0.163	NS
≤ 120	8.1
CSF protein
> 40	6.0	0.539	-
≤ 40	11.7
IT chemotherapy
No	3.6	0.010	NS
Yes	11.7
Radiotherapy
No	4.6	0.516	-
Yes	6.9
Cytologic response
No	5.1	0.002	0.030 (HR: 0.415, 95% CI: 0.188-0.918)
Yes	14.6

OS: Overall survival; PS (LMC): Performance status scale by Eastern Cooperative Oncology Group at leptomeningeal carcinomatosis; Hb (LMC): Hemoglobin at leptomeningeal carcinomatosis; MRI: Magnetic resonance imaging; CSF: Cerebrospinal fluid; IT: Intrathecal; HR: Hazard ration; CI: Confidence interval.