Transient and etiology-related transcription regulation in cirrhosis prior to hepatocellular carcinoma occurrence

Figure 5 Networks of etiology-independent or dependent transcript regulations in HCC-free cirrhosis. From 70 transcripts with a significantly different expression between alcoholic-associated vs HCV-associated cirrhosis vs CLs (P < 0.05, as in Figure 3), 23 transcripts (boxes) associated with different pathways were identified in Bibliosphere. In a context of HCC-free cirrhosis, etiology-specific arrows (alcoholism, blue; HCV, red) above the transcript indicates the direction of regulation: upward, downward or horizontal arrow: up-regulation, down-regulation or unchanged regulation. For a transcript with an up- (down-) regulation in both etiologies, the highest (lowest) arrow indicates the most marked dysregulation.