Brief Articles
Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Jan 21, 2009; 15(3): 356-365
Published online Jan 21, 2009. doi: 10.3748/wjg.15.356
Table 2 Up-regulated genes correlated with lymphatic metastasis
Gene nameSymbolaAccessionbFold changecpN1:pN0d
Cell adhesion proteins
CD58 antigen, (lymphocyte function-assocoated antigens)CD58NM_0017797.752.28
Integrin αMITGAMNM_0006325.042.06
Integrin β5ITGB5NM_0022133.981.87
Opioid-binding protein/cell adhesion molecule-likeOPCMLNM_002545
Cell membrane receptor
CD86 antigen, (CD28 antigen ligand 2, B7-2 antigen)CD86NM_0068896.762.33
v-jun sarcoma virus 17 oncogene homolog (avian)JUNNM_0022287.432.27
Met proto-oncogene (hepatocyte growth factor receptor)METNM_00024510.113.46
EphA2EPHA2NM_0044318.262.13
Epidermal growth factor receptor [avian erythroblastic leukemia viral (v-erb-b) oncogene homolog]EGFRNM_0052288.352.62
Cell death regulator
BCL2/adenovirus E1B 19kDa interacing protein 3BNIP3NM_0040523.882.29
Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4DSEMA4DNM_0063785.713.64
Intracellular signaling
Rho GDP dissociation inhibitor γARHGDIGNM_0011755.371.97
Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)RAC3AK0549934.632.07
Insulin-like growth factor binding protein 3IGFBP3M358785.392.15
Coagulation factor II (thrombin) receptorF2RNM_0019926.172.43
Growth/differentiation factor
Vascular endothelial growth factor CVEGFCNM_0054295.682.47
Cell cycle regulator
Cyclin D1 (PRAD1: parathyroid adenomatosis 1)CCND1NM_05305611.564.31
Cyclin-dependent kinase 4CDK4NM_0000758.733.59
Others
Tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)TIMP3NM_0003623.951.89
Ubiquitin-conjugating enzyme E2A (RAD6 homolog)UBE2ANM_0033364.381.95
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1YES1NM_0054335.662.37
P450(cytochrome) oxidoreductasePORAF2583414.741.99
Matrix metalloproteinase 13MMP13NM_002475.672.45
Matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV collagenase)MMP2NM_0045307.133.36