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Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Jul 28, 2009; 15(28): 3462-3471
Published online Jul 28, 2009. doi: 10.3748/wjg.15.3462
Table 2 Fibrosis progression in HCV and alcohol consumption from selected studies
No. of patientsAlcohol consumptionResultsRef.
22350 g, < 50 g, > 50 g> 50 g independent risk factor for fibrosis progression (P < 0.001)[26]
6664> 5/6 drinks (female/male), > 1 yearHigher risk of cirrhosis (35% vs 18 %)[27]
176> 40/60 g (female/male), > 5 yearsFaster cirrhosis progression (58 % vs 10 %), 2-3 fold increased risk of developing cirrhosis[29]
168Low < 30, medium 30-80; high > 80 g/d, > 5 JAlcohol consumption low/medium/high significantly different between non-cirrhotics (58%/27%/16%) and cirrhotics (76%/15%/9%) (P < 0.05)[28]
234Lifetime alcohol consumptionCirrhotics have greater alcohol consumption than patients with hepatitis (240 g/wk vs 146 g/wk) (P = 0.02)[30]
2330, 25, 50, 75, 100, > 125 gWeekly alcohol consumption correlates with serum HCV RNA levels and fibrosis score (P < 0.001)[23]
7020/175 g/dHCV increases OR for cirrhosis from 1 to 15 (0 g), 9.2 to 147.2 (175 g)[141]
1667Subgroup: > 260 g/wk vs < 90 g/wkRisk for cirrhosis increases by 3.6[31]
636> 80RR for cirrhosis: HCV 7.8, HCV + alcohol 31.1[32]