What is the most cost-effective strategy to screen for second primary colorectal cancers in male cancer survivors in Korea?

doi:10.3748/wjg.15.3153

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2009; 15(25): 3153-3160
Published online Jul 7, 2009. doi: 10.3748/wjg.15.3153

Table 3 Two-way sensitivity analysis by changing variables of index cancer such as 5-yr survival rate of first cancer and relative risk of colorectal cancer in Korean male cancer survivors

Relative risk of colorectal cancer in cancer survivor compared with that in general population	5-yr survival of index cancer = 20%				5-yr survival of index cancer = 40%				5-yr survival of index cancer = 80%
	Non-dominated strategy	Lifetime cost per person (dollar)¹	Life expectancy (yr)	Incremental C/E² (dollar)¹ per life-year gained	Non-dominated strategy	Lifetime cost per person (dollar)¹	Life expectancy (yr)	Incremental C/E² (dollar)¹ per life-year gained	Non-dominated strategy	Lifetime cost per person (dollar)¹	Life expectancy (yr)	Incremental C/E² (dollar)¹ per life-year gained
5	COL5	329.0	4.512		COL5	532.5	7.567		COL5	957.9	13.829
	COL3	339.2	4.514	4921.7	COL3	542.2	7.571	2634.4	COL3	962.6	13.836	658.2
4	COL5	306.7	4.516		COL5	463.5	7.572		COL10	826.0	13.837
	COL3	329.0	4.517	18 078.3	COL3	480.2	7.575	5592.9	COL5	831.1	13.843	835.2
									COL3	879.7	13.847	11 508.2
3	COL10	266.6	4.517		COL10	401.4	7.576		COL10	682.9	13.847
	COL5	270.3	4.518	2685.2	COL5	409.6	7.579	3365.6	COL5	701.9	13.851	4104.9
	COL3	295.5	4.519	27 126	COL3	447.3	7.580	22 760.2	COL3	761.9	13.854	18 922.1
2	No screening	185.4	4.512		COL10	324.4	7.582		COL10	533.5	13.857
	COL10	224.5	4.52	4912	COL5	340.1	7.583	9506.4	COL5	566.7	13.860	10 725.2
	COL5	232.3	4.521	8378.3	COL3	383.7	7.584	39 469.5	COL3	638.6	13.862	34 075.6
	COL3	260.4	4.522	45 556.4
1	No screening	96.1	4.519		No screening	175.9	7.580		No screening	342.6	13.853
	COL10	180.5	4.523	20 568.2	COL10	244.0	7.587	9196.3	COL10	377.2	13.867	2424.5
	COL5	192.4	4.524	25 817.6	COL5	267.2	7.588	28 343.9	COL5	425.1	13.869	31 064.6
	COL3	223.5	4.524	103 111.0	COL3	316.8	7.589	91 808.0	COL3	509.3	13.870	81 681.8

COL10: Colonoscopy every 10 years; COL5: Colonoscopy every 5 years; COL3: Colonoscopy every 3 years; Dominated strategy is a strategy that is more or equally costly and less effective than a competing strategy.

¹Exchange rate, 955 Korean won for one US dollar in 2006;

²Incremental CE ratio (dollar/year) = Incremental cost per person/Incremental years of life gained.

Citation: Park SM, Kim SY, Earle CC, Jeong SY, Yun YH. What is the most cost-effective strategy to screen for second primary colorectal cancers in male cancer survivors in Korea? World J Gastroenterol 2009; 15(25): 3153-3160
URL: https://www.wjgnet.com/1007-9327/full/v15/i25/3153.htm
DOI: https://dx.doi.org/10.3748/wjg.15.3153