Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein

Figure 1 L-81 reduced obesity. A: Body appearances of lean control (left), untreated db/db (middle), and db/db mice fed with chow sprayed with 1% L-81 (right); B: Weight of db/db mice or lean control mice receiving different drug treatments over an observation period of 30 d (n = 3 in each group); C: Plasma total cholesterol and (D) plasma triglyceride level of mice treated with the indicated drugs; E: The size of adipocytes in epididymal fat pads of mice treated with the indicated drugs as observed under 100 × magnification.