Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma

Figure 4 Knock-down DNMT1 induces cell apoptosis in HCC cell lines. A: The SMMC-7721 cells were transfected stably with DNMT1 siRNA for 2 mo and apoptosis was detected by FACS; B: Knock-down DNMT1 induced apoptosis gene PDCD4 expression in 7721-MT1 cell line compared with control cell line by quantitative real-time PCR. ^aShow the significant difference between 7721-pMT1 and control.