Editorial
Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Apr 7, 2009; 15(13): 1548-1553
Published online Apr 7, 2009. doi: 10.3748/wjg.15.1548
Table 3 Response to treatment
StudyDefinition of responseResponse
Change in abdominal pain score (No. of patients)
TCAPlaceboTCAPlacebo
Vahedi et al[16], 2008Complete loss of symptoms (total score= 0) at the end of the study or at least two scores with a decrease in the number of symptoms17/2510/25--
Talley et al[17], 2008Adequate relief of IBS symptoms over 50% of the weeks10/189/16  -45.3 ± 26.3 (18)  -7.4 ± 46.9 (16)
Morgan et al[18], 2005Improvement of IBS symptoms determined by patients13/225/22--
Rajagopalan et al[19], 1998Global well-being: patients were asked to estimate at the post-treatment interview how much better or worse they were on the whole (in percentage) as compared to the pretrial period7/113/11--
Vij et al[20], 1991Improvement of 50% or above in IBS symptoms11/215/23--
Greenbaum et al[21], 1987Global assessment of improvement15/285/28-58.96 ± 19.37 (28)-13.93 ± 17.76 (28)
Tripathi et al[22], 1983Improvement of 50% or above in IBS symptoms7/254/25--