Melatonin protects liver from intestine ischemia reperfusion injury in rats

Table 1 ALT, AST, TNF-α, MDA and ICAM-1 in rats with ischemia-reperfusion injury (mean ± SD)

Group	Time (h)	Serum ALT (μkat/L)	Serum AST (μkat/L)	Serum TNF-α(pg/mL)	MDA in liver (nmol/g)	ICAM-1 in liver (%)
Melatonin	0.5	1.8 ± 0.6a	1.8 ± 0.6a	8.2 ± 2.9	23.7 ± 4.3	2.9 ± 1.2
	1	1.6 ± 0.5a	1.6 ± 0.5a	10.9 ± 3.0	28.3 ± 5.1	3.0 ± 0.9
	6	1.5 ± 0.5a	1.5 ± 0.5a	14.8 ± 3.8a	42.0 ± 5.2a	4.0 ± 1.4a
	12	1.4 ± 0.4a	1.4 ± 0.4a	18.0 ± 3.3a	55.2 ± 5.4a	11.8 ± 3.3a
	24	1.3 ± 0.4a	1.3 ± 0.4a	15.7 ± 3.3	82.7 ± 6.1a	6.9 ± 2.7a
Alcohol	0.5	3.1 ± 0.3	3.1 ± 0.3	8.8 ± 2.5	27.7 ± 5.9	2.4 ± 1.3
	1	3.0 ± 0.6	3.0 ± 0.6	11.8 ± 3.7	33.2 ± 6.3	2.5 ± 0.7
	6	2.5 ± 0.4	2.5 ± 0.4	20.9 ± 4.3	54.3 ± 6.5	7.0 ± 2.3
	12	2.4 ± 0.4	2.4 ± 0.4	23.5 ± 4.3	79.1 ± 6.2	22.4 ± 4.3
	24	2.1 ± 0.5	2.1 ± 0.5	17.7 ± 3.9	106.2 ± 7.1	16.0 ± 3.2
NS	0.5	3.3 ± 0.4	3.3 ± 0.4	9.4 ± 2.8	29.5 ± 6.3	2.8 ± 0.8
	1	2.9 ± 0.5	2.9 ± 0.5	11.6 ± 3.3	34.1 ± 5.4	2.6 ± 1.3
	6	2.6 ± 0.4	2.6 ± 0.4	21.4 ± 5.0	53.8 ± 6.1	6.8 ± 2.2
	12	2.5 ± 0.4	2.5 ± 0.4	24.4 ± 4.9	83.3 ± 5.2	21.4 ± 5.4
	24	2.2 ± 0.4	2.2 ± 0.4	16.3 ± 3.6	108.5 ± 9.8	14.3 ± 2.8

^aP < 0.05 vs alcohol solvent and NS control groups.