Lack of nitrate tolerance in isosorbide dinitrate- and sodium nitroprusside-induced relaxation of rabbit internal anal sphincter

doi:10.3748/wjg.14.4667

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 7, 2008; 14(29): 4667-4671
Published online Aug 7, 2008. doi: 10.3748/wjg.14.4667

Table 1 Maximum relaxation responses (E_max) and pD2 values to agonists in strips of internal anal sphincter smooth muscle from two groups of rabbits (n = 6 each experiments)

		Control	ISDN-induced tolerance
ISDN	E_max	74.4 ± 7.2	75.0 ± 6.7
ISDN	pD2	5.48 ± 0.05	5.40 ± 0.06
SNP	E_max	96.7 ± 3.3	98.8 ± 1.4
SNP	pD2	5.48 ± 0.05	5.57 ± 0.05
EFS	E_max	72.5 ± 7.4	78.1 ± 6.3

E_max: The maximum relaxation response (percentage of papaverine induced relaxations); pD2: Negative logarithm of the EC₅₀ value.

Citation: Koyuncu A, Bagcivan I, Sarac B, Aydin C, Yildirim S, Sarioglu Y. Lack of nitrate tolerance in isosorbide dinitrate- and sodium nitroprusside-induced relaxation of rabbit internal anal sphincter. World J Gastroenterol 2008; 14(29): 4667-4671
URL: https://www.wjgnet.com/1007-9327/full/v14/i29/4667.htm
DOI: https://dx.doi.org/10.3748/wjg.14.4667