Experimental treatment of pancreatic cancer with two novel histone deacetylase inhibitors

doi:10.3748/wjg.14.3681

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Jun 21, 2008 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2008; 14(23): 3681-3692
Published online Jun 21, 2008. doi: 10.3748/wjg.14.3681

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Figure 2 Mechanism of drug action after in vitro treatment with NVP-LAQ824 and NVP-LBH589 for 24 h. A and B: Acetylation of histone H4. Protein extracts from HELA cells that were treated with 5 mmol/L sodium butyrate served as positive controls; C and D: p21^WAF-1/CIP-1 expression. Cell lysate from HCT 116 colon cancer cells served as positive control; A-D: Staining with β-actin antibody confirmed equal protein loading.

Citation: Haefner M, Bluethner T, Niederhagen M, Moebius C, Wittekind C, Mossner J, Caca K, Wiedmann M. Experimental treatment of pancreatic cancer with two novel histone deacetylase inhibitors. World J Gastroenterol 2008; 14(23): 3681-3692
URL: https://www.wjgnet.com/1007-9327/full/v14/i23/3681.htm
DOI: https://dx.doi.org/10.3748/wjg.14.3681