Clinical Research
Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jun 21, 2008; 14(23): 3662-3671
Published online Jun 21, 2008. doi: 10.3748/wjg.14.3662
Table 4 Associations between serum folate/vitamin B12 concentrations and tumor methylation in relation to the clinical-biological characteristics of patients
Variablesn(%)Folate (ng/mL) mean (range)P1High folate/Low folate2n (%)P3Vit.B12 (pg/mL) mean (range)P1High B12/Low B122n (%)P3
Controls (81)6.3 (3.8-12)0.1449 (60.5)/32(39.5)0.64312.8 (108-995)0.1440 (49.4)/41 (50.6)0.94
Total cases (86)5.9 (2.1-12)48 (55.8)/38(44.2)269 (50-681)44 (51.2)/42 (48.8)
Unmethylated66 (76.7)5.7 (2.4-12)32 (48.5)/34 (51.5)255.2 (79-681)29 (43.9)/37 (56.1)
Methyalated20 (23.3)6.4 (2.1-10)0.0616 (80)/4 (20)0.02314.7 (50-571)0.115 (75)/5 (25)0.02
Sex
Male (55)5.9 (2.4-12)29 (52.7)/26 (47.3)274.2 (67-681)28 (50.9)/27(49.1)
Unmethylated43 (78.2)5.8 (2.4-12)19 (44.2)/24 (55.8)325.5 (67-571)18 (41.9)/25 (58.1)
Methylated12 (21.8)6.5 (3.9-9.5)0.110 (83.3)/2 (16.7)0.02254.4 (83-681)0.0410 (83.3)/2 (16.7)0.02
Female (31)5.7 (2.1-10)0.6519 (61.3)/12 (38.7)0.55259.7 (50-523)0.7516(51.6)/15 (48.4)1.005
Unmethylated23 (74.2)5.6 (3-8)13 (56.5)/10 (43.5)260. 3 (79-521)11 (47.8)/12 (52.2)
Methylated8 (25.8)6.2 (2.1-10)0.46 (75)/2 (25)0.4257.8 (50-523)0.95 (62.5)/3 (37.5)0.7
Age
< 60 yr (36)5.4 (2.1-8)18 (50)/18 (50)238.1(50-571)14 (38.9)/22(61.1)
Unmethylated30 (83.3)5.4 (3-8)14 (46.7)/16 (53.3)229.8 (79-465)11 (36.7)/19 (63.3)
Methylated6 (16.7)5.5 (2.1-7.9)0.54 (66.6)/2 (33.3)0.7279.5 (50-571)0.83 (50)/3 (50)0.7
≥ 60 yr (50)6.3 (2.4-12)0.04530 (60)/20 (40)0.45291.3 (67-681)0.1530 (60)/20(40)0.15
Unmethylated36 (72)6.1 (2.4-12)18 (50)/18 (50)276.3 (83-681)18 (50)/18 (50)
Methylated14 (28)6.8 (3.9-10)0.112 (85.7)/2 (14.3)0.03329.7 (67-543)0.112 (85.7)/2 (14.3)0.03
Site
Distal (62)5.8 (2.4-12)32 (51.6)/30 (48.4)260.6 (79-681)28 (45.2)/34 (54.8)
Unmethylated61 (98.4)5.8 (2.4-12)31 (50.8)/30 (49.2)255.5 (79-681)27 (44.3)/34 (55.7)
Methylated1 (1.6)7.90.31 (100)/0 (0)ND271 (271)0.11 (100)/0 (0)ND
Proximal (24)6.1 (2.1-10)0.4516 (66.7)/8 (33.3)0.25290.7 (50-543)0.5516 (66.7)/8 (33.3)0.15
Unmethylated5 (20.8)5.3 (4.5-6.4)1 (20)/4 (80)251 (109-483)2 (40)/3 (60)
Methylated19 (79.2)6.3 (2.1-10)0.0615 (78.9)/4 (21.1)0.03301.2 (50-543)0.514 (73.7)/5 (26.3)0.3

  • Citation: Mokarram P, Naghibalhossaini F, Firoozi MS, Hosseini SV, Izadpanah A, Salahi H, Malek-Hosseini SA, Talei A, Mojallal M. Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B12 status. World J Gastroenterol 2008; 14(23): 3662-3671
  • URL: https://www.wjgnet.com/1007-9327/full/v14/i23/3662.htm
  • DOI: https://dx.doi.org/10.3748/wjg.14.3662