Genome-wide differences in hepatitis C- vs alcoholism-associated hepatocellular carcinoma

Figure 4 Data validation by qRTPCR of tumor mRNAs. The levels of 23 transcripts (listed from Figures 2A and 3A; SAA1 and -2 are counted as 2 transcripts) were determined in tumors and normalized with the 18S RNA level. A: Every histogram depicts the mean transcript level in all patients from Table 1 (n = 35) and is expressed as a percentage of the mean level in alcoholic patients (100%). Mann and Whitney’s test (^aP < 0.05; ^bP < 0.01). B: UHC made with qRTPCR data from our test set (n = 13). The colors in dendrogram indicate the percentage of iterations reproducibly providing the same separation. Note the significant separation of 2 major, etiology-related branches (black branches found in 100% of 10³ iterations).