Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump

Table 3 Characteristics of patients with oral CIC

Patient ID	Oral contraceptive	Age (yr)	Exposure time	Liver parameters					Comments		Genotypes of SNPs
				ALT	AP	γGT	tBili	tBA	Clinical features	Histology	ABCB111331T>C (V444A)	ABCC23600T>A (V1188E)	ABCC24581G>A (C1515Y)
				(ULN)	(ULN)	(ULN)	(ULN)	(ULN)
11	30 &mgr;g ethinylestradiol/75 &mgr;g gestodene	32	nd	4.9	1.7	1	10.9	22.3	Jaundice	Intrahepatic cholestasis	CC	TT	GG
2	30 &mgr;g ethinylestradiol/150 &mgr;g levonorgestrel	15	21 d	1	3	1	4.2	nd	Jaundice, nausea, pruritus	Extensive intrahepatic cholestasis	CC	TT	GG
3	35 &mgr;g ethinylestradiol/50 &mgr;g levonorgestrel	40	2 yr	3.9	2.8	3.6	0.5	1.6	Pruritus	Bland	CC	TT	GG
4	35 &mgr;g ethinylestradio/2 mg cyproteron	34	nd	1	1.3	nd	2.8	1.6	Jaundice	Extensive canalicular cholestasis, mild portal inflamation	CC	TA	GA

¹Patient exhibited previous episodes of ICP.