Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype

Figure 1 Treatment with ZK191784 ameliorates intestinal inflammation in acute and chronic DSS colitis. A: Acute DSS colitis was induced by administration of 3% DSS for 7 d. ^aP < 0.05, n = 5 mice per group. Data presented are representative of three independent experiments; B: Administration of ZK191785 was started after the first and the third cycle of DSS administration for induction of chronic colitis. ^cP < 0.05, n = 8 or 9 mice per group. Data show one of two independent experiments. Data are displayed as box plots in which the box contains the middle half of the scores in the distribution, the median is shown as a line across the box, and the largest value below the upper hinge and the smallest value above the lower inner fence are indicate the distribution; C: Representative colonic hematoxylin/eosin sections from animals with acute DSS colitis treated with ZK191784 or vehicle (× 100).