Chronic hepatitis C virus infection: Prevalence of extrahepatic manifestations and association with cryoglobulinemia in Bulgarian patients

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Dec 28, 2007; 13(48): 6518-6528
Published online Dec 28, 2007. doi: 10.3748/wjg.v13.i48.6518

Table 1 Prevalence of clinical and biological extrahepatic manifestations in 136 patients with chronic HCV infection

Clinical manifestations	n (%)
Fatigue	81 (59.6)
Renal involvement	34 (25.0)
Type 2 diabetes mellitus	31 (22.8)
Paresthesia	27 (19.9)
Arthralgia	25 (18.4)
Purpura	24 (17.6)
Pulmonary fibrosis	21 (15.4)
Thyroid dysfunction	20 (14.7)
Raynaud's phenomenon	16 (11.8)
B-cell lymphoma	12 (8.8)
Sicca-syndrome (xerostomia)	9 (6.6)
Lichen planus	8 (5.9)
Biological manifestations
Cryoglobulinemia	51 (37.5)
Thrombocytopenia	4 (31.6)
ANA	25 (18.4)
АSMА	23 (16.9)
АNCA	18 (13.2)
Аnticardiolipin antibodies	12 (8.8)
Overall
At least 1 extrahepatic manifestation	104 (76.5)

ANA: Anti-nuclear antibodies; АSMА: Anti-smooth muscle antibodies; АNCA: Anti-neutrophil cytoplasm antibodies.

Citation: Stefanova-Petrova DV, Tzvetanska AH, Naumova EJ, Mihailova AP, Hadjiev EA, Dikova RP, Vukov MI, Tchernev KG. Chronic hepatitis C virus infection: Prevalence of extrahepatic manifestations and association with cryoglobulinemia in Bulgarian patients. World J Gastroenterol 2007; 13(48): 6518-6528
URL: https://www.wjgnet.com/1007-9327/full/v13/i48/6518.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i48.6518

Stefanova-Petrova DV, Tzvetanska AH, Naumova EJ, Mihailova AP, Hadjiev EA, Dikova RP, Vukov MI, Tchernev KG. Chronic hepatitis C virus infection: Prevalence of extrahepatic manifestations and association with cryoglobulinemia in Bulgarian patients. World J Gastroenterol 2007; 13(48): 6518-6528 [PMID: 18161922 DOI: 10.3748/wjg.v13.i48.6518]

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