Decreased expression of serotonin in the jejunum and increased numbers of mast cells in the terminal ileum in patients with irritable bowel syndrome

Figure 5 Mast cells after staining by mouse anti-human tryptase antibody under a powerful microscope (× 400). A-C: Mast cells at the descending part of the duodenum in healthy controls, IBS-C patients and IBS-D patients, respectively; D-F: Mast cells at the proximal end of jejunum in healthy controls, IBS-C patients and IBS-D patients, respectively; G-I: Mast cells at the terminal ileum in healthy controls, IBS-C patients and IBS-D patients, respectively. EC cell: Enterochromaffin cells; 5-HT: Serotonin; IBS: Irritable bowel syndrome; IBS-C: Constipation predominant IBS; IBS-D: Diarrhea predominant IBS.